A 46 yo F with new breast cancer will be starting adjuvant dose-dense AC (doxorubicin-cyclophosphamide). PMH: cesarean section x2, G2P2 with hyperemesis gravidarum in both pregnancies; non-smoker, no alcohol use. Her labs are all WNL. Her home medications include: multivitamin 1 tablet daily, oxycodone 5 mg/APAP 325mg 1 tablet every 4 hours as needed for pain after surgery. Which antiemetic regimen would you recommend to prevent acute CINV prior to cycle 1 of chemotherapy, based on ASCO guidelines? |